The show, titled Fern, had the 53-year-old presenter interviewing celebrities and showcasing real-life stories when it began in March.
The show started with just 994,000 viewers, a third less than Channel 4’s usual 5pm slot.
Channel 4 bosses had high hopes after signing up Fern after she successfully guest-hosted The 5 O’Clock Show last year, beating Peter Andre, who was also a presenter, to the role.
The show, which replaced Paul O’Grady’s chat show when he moved to ITV, was averaging just 970,000 towards the end of its run.
Channel 4’s chief creative officer Jay Hunt yesterday confirmed that the show would not be coming back – and paid tribute to Fern.
She said: “At the end of the day it didn’t really cut through with viewers – and we have to learn from that. Fern is a fantastic daytime talent and I wouldn’t hesitate to work with her again, but that particular show didn’t work.”
The show’s viewing figures was way down on hit shows earlier in the year such as Coach Trip and Come Dine With Me, which pulled in 2.4 million.