The Toon Army are in desperate need of points after a recent poor run of form.
Newcastle have only scored one point in their last five matches, and so will be hoping to gain something against mid-table Leicester, who have won their last two games.
Also on today there is a London derby as West Ham face Chelsea; Norwich take on Sheffield Wednesday in the Championship; and in the National League Macclesfield host Wrexham.
Newcastle United v Leicester City is on BT Sport 1 at 17.00 (kick-off 17.30).
West Ham United v Chelsea is on Sky Main Event and Sky Premier League at 11.30 (kick-off 12.30).
Norwich City v Sheffield Wednesday is on Sky Main Event and Sky Football at 17.15 (kick-off 17.30).
Macclesfield Town v Wrexham is on BT Sport 1 at 12.00 (kick-off 12.30).